Never use with Tramadol

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Certain medications are contraindicated when Ultram® is used. It should never be used with other SSRIs (Prozac®, Zoloft®, Paxil®, Luvox® for example) since this can cause a rare complication called serotonin syndrome. Severe cases of this condition may result in seizures and death. As much as having serotonin is a good thing, too much in the body is potentially deadly. Other drugs that hazard some risk of creating serotonin syndrome include monoamine oxidase inhibitors, or first generation antidepressants. When patients take any type of antidepressant they should make sure doctors are aware of this fact before they take tramadol.